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B6db activities:
Description 4-hydroxyphenylacetaldehyde synthase
Alternative names TYRDC-2 (gene name)
Catalyzed reaction L-tyrosine + O(2) = 4-hydroxyphenylacetaldehyde + H(2)O(2) + NH(3) + CO(2).
Cofactor Pyridoxal-phosphate.
Comments A pyridoxal 5'-phosphate protein. The enzyme, isolated from the the plant Petroselinum crispum (parsley), catalyses the production of 4-hydroxyphenylacetaldehyde directly from L-tyrosine. Tyramine is not formed as an intermediate. The enzyme has a low activity with L-dopa (cf. EC, 3,4-dihydroxyphenylacetaldehyde synthase).
Organisms -Plants
Links Enzyme (activities)
BRENDA (activities)
KEGG (pathways)
PLPMDB (PLP mutants)
 Torrens-Spence MP1, Liu P, Ding H, Harich K, Gillaspy G, Li J (2013) Biochemical evaluation of the decarboxylation and decarboxylation-deamination activities of plant aromatic amino acid decarboxylases J Biol Chem 288 2376-87.

 Torrens-Spence MP, Gillaspy G, Zhao B, Harich K, White RH, Li J (2012) Biochemical evaluation of a parsley tyrosine decarboxylase results in a novel 4-hydroxyphenylacetaldehyde synthase enzyme Biochem Biophys Res Commun 418 211-6.

Articles on
last changed 2018/05/09 15:51

B6db activities