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B6db activities:
Description Phenylacetaldehyde synthase
Alternative names PAA synthase.
aromatic aldehyde synthase.
L-phenylalanine decarboxylase-oxidase.
L-phenylalanine carboxy-lyase (oxidative-deaminating)
PAAS (gene name)
Catalyzed reaction L-phenylalanine + O(2) + H(2)O <=> phenylacetaldehyde + CO(2) + NH(3) + H(2)O(2).
Cofactor Pyridoxal-phosphate.
Comments A pyridoxal 5'-phosphate protein. The enzyme, isolated from the the plants Petunia hybrida and a Rosa hybrid, catalyses the production of phenylacetaldehyde directly from L-phenylalanine. The enzyme is specific for L-phenylalanine and does not accept other aromatic amino acids as substrates.
The plant enzyme catalyses the decarboxylation of phenylalanine to phenylethylamine and the subsequent oxidation of phenyethylamine to phenylacetaldehyde.
Phenylacetaldehyde is a constituent of the floral scent and precursor of both phenylethanol (another scent costituent) and phenylacetic acid (an auxin)
Organisms -Plants


Links Enzyme (activities)
BRENDA (activities)
KEGG (pathways)
PLPMDB (PLP mutants)
 Günther J, Lackus ND, Schmidt A, Huber M, Stödtler HJ, Reichelt M, Gershenzon J, Köllner TG (2019) Separate Pathways Contribute to the Herbivore-Induced Formation of 2-Phenylethanol in Poplar Plant Physiol 180 767-782.

 Torrens-Spence MP, Pluskal T, Li FS, Carballo V, Weng JK (2018) Complete Pathway Elucidation and Heterologous Reconstitution of Rhodiola Salidroside Biosynthesis Mol Plant 11 205-217.

 Achmon Y, Ben-Barak Zelas Z, Fishman A. (2014) Cloning Rosa hybrid phenylacetaldehyde synthase for the production of 2-phenylethanol in a whole cell Escherichia coli system Appl Microbiol Biotechnol 98 3603-11.

 Torrens-Spence MP, von Guggenberg R, Lazear M, Ding H, Li J. (2014) Diverse functional evolution of serine decarboxylases: identification of two novel acetaldehyde synthases that uses hydrophobic amino acids as substrates BMC Plant Biol 14 247.

 Gutensohn M, Klempien A, Kaminaga Y, Nagegowda DA, Negre-Zakharov F, Huh JH, Luo H, Weizbauer R, Mengiste T, Tholl D, Dudareva N. (2011) Role of aromatic aldehyde synthase in wounding/herbivory response and flower scent production in different Arabidopsis ecotypes. Plant J. 66 591-602.

 Kaminaga Y, Schnepp J, Peel G, Kish CM, Ben-Nissan G, Weiss D, Orlova I, Lavie O, Rhodes D, Wood K, Porterfield DM, Cooper AJ, Schloss JV, Pichersky E, Vainstein A, Dudareva N. (2006) Plant phenylacetaldehyde synthase is a bifunctional homotetrameric enzyme that catalyzes phenylalanine decarboxylation and oxidation J Biol Chem 281 23357-66.

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last changed 2018/05/03 11:05

B6db activities