B6db activities : 4_1_1

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	4.1.1.117
Description	2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate decarboxylase
Alternative names	citryl-L-2,3-diaminopropionate decarboxylase; SbnH (gene name);
Catalyzed reaction	2-((L-alanin-3-ylcarbamoyl)methyl)-2-hydroxybutanedioate <=> 2-((2-aminoethylcarbamoyl)methyl)-2-hydroxybutanedioate + CO(2)
Cofactor	Pyridoxal-phosphate.
Comments	The enzyme, characterized from the bacterium Staphylococcus aureus, participates in the biosynthesis of the siderophore staphyloferrin B.
PDB	6KNI;
Organisms	-Eubacteria

Links	Enzyme (activities) 4.1.1.117 BRENDA (activities) 4.1.1.117 KEGG (pathways) 4.1.1.117 PLPMDB (PLP mutants) 4.1.1.117

References	Tang J, Ju Y, Gu Q, Xu J, Zhou H (2019) Structural insights into substrate recognition and activity regulation of the key decarboxylase SbnH in staphyloferrin B biosynthesis J Mol Biol 431 4868-4881. Cheung J, Beasley FC, Liu S, Lajoie GA, Heinrichs DE (2009) Molecular characterization of staphyloferrin B biosynthesis in Staphylococcus aureus Mol Microbiol 74 1594-608. Articles on 4.1.1.117

last changed	2019/10/23 12:50