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B6db activities:
Description Ornithine decarboxylase
Alternative names ODC.
Catalyzed reaction L-ornithine = putrescine + CO(2).
Cofactor Pyridoxal-phosphate.
Comments In mammals, ornithine decarboxylase catalyzes the rate-limiting step of the pathway leading to the production of polyamines, which play an essential role in cell proliferation.
Subfamily 1 includes enzymes that belong to the fold type III group and are mostly of eukaryotic origin.
Family 2 includes only eubacterial enzymes, beloging to the fold type I group.
Prosite PROSITE; PDOC00585; PROSITE; PDOC00685;
Organisms -Eubacteria -Plants -Fungi -Metazoa -Human


Links Enzyme (activities)
BRENDA (activities)
KEGG (pathways)
PLPMDB (PLP mutants)
 Romano A, Trip H, Lolkema JS, Lucas PM (2013) Three-component lysine/ornithine decarboxylation system in Lactobacillus saerimneri 30a J Bacteriol 195 1249-54.

 Docimo T, Reichelt M, Schneider B, Kai M, Kunert G, Gershenzon J, D'Auria JC. (2012) The first step in the biosynthesis of cocaine in Erythroxylum coca: the characterization of arginine and ornithine decarboxylases. Plant Mol Biol. 78 599-615.

 de las Rivas B, Marcobal A, Muņoz R. (2007) Gene organization of the ornithine decarboxylase-encoding region in Morganella morganii J Appl Microbiol 102 1551-60.

 Lee J, Michael AJ, Martynowski D, Goldsmith EJ, Phillips MA. (2004) Phylogenetic diversity and the structural basis of substrate specificity in the beta/alpha-barrel fold basic amino acid decarboxylases J Biol Chem 282 27115-25.

 Lee JH, Son MY, Yoon MY, Choi JD, Kim YT. (2004) Isolation and characterization of ornithine decarboxylase gene from flounder (Paralichthys olivaceus) Mar Biotechnol (NY) 6 453-62.

 Shah R, Coleman CS, Mir K, Baldwin J, Van Etten JL, Grishin NV, Pegg AE, Stanley BA, Phillips MA. (2004) Paramecium bursaria chlorella virus-1 encodes an unusual arginine decarboxylase that is a close homolog of eukaryotic ornithine decarboxylases J Biol Chem 279 35760-7.

 Lee, Y.S.; Cho, Y.D. (2001) Identification of essential active-site residues in ornithine decarboxylase of Nicotiana glutinosa decarboxylating both L-ornithine and L-lysine Biochem J 360 657-65.

 Almrud, J. J.; Oliveira, M. A.; Kern, A. D.; Grishin, N. V.; Phillips, M. A.; Hackert, M. L. (2000) Crystal structure of human ornithine decarboxylase at 2.1 A resolution: structural insights to antizyme binding J Mol Biol 295 7-16..

 Guevara-Olvera, L.; Hung, C.Y.; Yu, J.J.; Cole, G.T. (2000) Sequence, expression and functional analysis of the Coccidioides immitis ODC (ornithine decarboxylase) gene Gene 25 437-48.

 Takatsuka, Y.; Yamaguchi, Y.; Ono, M.; Kamio, Y. (2000) Gene cloning and molecular characterization of lysine decarboxylase from Selenomonas ruminantium delineate its evolutionary relationship to ornithine decarboxylases from eukaryotes J Bacteriol 182 6732-41.

 Klein, R. D.; Favreau, M. A.; Alexander-Bowman, S. J.; Nulf, S. C.; Vanover, L.; Winterrowd, C. A.; Yarlett, N.; Martinez, M.; Keithly, J. S.; Zantello, M. R.; Thomas, E. M.; Geary, T. G. (1997) Haemonchus contortus: cloning and functional expression of a cDNA encoding ornithine decarboxylase and development of a screen for inhibitors Exp Parasitol 87 171-84.

 Michael, A.J.; Furze, J.M.; Rhodes M.J.; Burtin D. (1996) Molecular cloning and functional identification of a plant ornithine decarboxylase cDNA Biochem J 314 241-8.

 Niemann, G.; von Besser, H.; Walter, R. D. (1996) Panagrellus redivivus ornithine decarboxylase: structure of the gene, expression in Escherichia coli and characterization of the recombinant protein Biochem J 317 135-40.

 Momany, C.; Ernst, S.; Ghosh, R.; Chang, N. L.; Hackert, M. L. (1995) Crystallographic structure of a PLP-dependent ornithine decarboxylase from Lactobacillus 30a to 3.0 A resolution J Mol Biol 252 643-55.

 Boyle SM, Barroso L, Moore RC, Wright JM, Patel T. (1994) Primary structure of the speC gene encoding biosynthetic ornithine decarboxylase in Escherichia coli Gene 151 157-60.

 Hackert, M. L.; Carroll, D. W.; Davidson, L.; Kim, S. O.; Momany, C.; Vaaler, G. L.; Zhang, L. (1994) Sequence of ornithine decarboxylase from Lactobacillus sp. strain 30a J Bacteriol 176 7391-4.

 Fonzi, W. A. (1989) Biochemical and genetic characterization of the structure of yeast ornithine decarboxylase Biochem Biophys Res Commun 162 1409-16.

 Brabant, M.; McConlogue, L.; van Daalen Wetters, T.; Coffino, P. (1988) Mouse ornithine decarboxylase gene: cloning, structure, and expression Proc Natl Acad Sci U S A 85 2200-4.

 Phillips, M. A.; Coffino, P.; Wang, C. C. (1987) Cloning and sequencing of the ornithine decarboxylase gene from Trypanosoma brucei. Implications for enzyme turnover and selective difluoromethylornithine inhibition J Biol Chem 262 8721-7.

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last changed 2019/06/20 13:39

B6db activities