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B6db activities: 4.1.1.18

4.1.1.18
Description Lysine decarboxylase.
Catalyzed reaction L-lysine = cadaverine + CO(2).
Cofactor Pyridoxal-phosphate.
Comments -!- Also acts on 5'-hydroxy-L-lysine.
In bacteria, the production of cadaverine by lysine decarboxylase appears to be a mechanism of resistance to acidic pH values.

Several PDB structures (proteins from Arabidopsis and Thermus) are annotated as possible Lys decarboxylases, but the proteins are small and unrelated to the validated PLP-dependent enzymes with this activity.

Prosite PROSITE; PDOC00585;
PDB 3N75; 3Q16;
Organisms -Bacteria -Plants
 

Family 

4.1.1.18_a (10) 4.1.1.18_b (8) 4.1.1.18_c (10)
 
Links Enzyme (activities) 4.1.1.18
BRENDA (activities) 4.1.1.18
KEGG (pathways) 4.1.1.18
PLPMDB (PLP mutants) 4.1.1.18
 
References
 Bunsupa S, Katayama K, Ikeura E, Oikawa A, Toyooka K, Saito K, Yamazaki M. (2012) Lysine decarboxylase catalyzes the first step of quinolizidine alkaloid biosynthesis and coevolved with alkaloid production in leguminosae. Plant Cell. 24 1202-16.

 Burrell M1, Hanfrey CC, Kinch LN, Elliott KA, Michael AJ. (2012) Evolution of a novel lysine decarboxylase in siderophore biosynthesis. Mol Microbiol 485 1365-2958.

 Kanjee U1, Gutsche I, Alexopoulos E, Zhao B, El Bakkouri M, Thibault G, Liu K, Ramachandran S, Snider J, Pai EF, Houry WA. (2011) Linkage between the bacterial acid stress and stringent responses: the structure of the inducible lysine decarboxylase. EMBO J. 30 931-44.

 Levine, M.; Progulske-Fox, A.; Denslow, N.D.; Farmerie, W.G.; Smith, D.M.; Swearingen, W.T.; Miller, F.C.; Liang, Z.; Roe, B.A.; Pan, H.Q. (2001) Identification of lysine decarboxylase as a mammalian cell growth inhibitor in Eikenella corrodens: possible role in periodontal disease Microb Pathog 30 179-92.

 Lemonnier, M.; Lane, D. (1998) Expression of the second lysine decarboxylase gene of Escherichia coli Microbiology 144 751-60.

 Fecker, L.F.; Beier, H.; Berlin, J. (1986) Cloning and characterization of a lysine decarboxylase gene from Hafnia alvei Mol Gen Genet 203 177-184.

Articles on 4.1.1.18
 
last changed 2014/03/20 12:10

B6db activities