B6db activities : 4_1_1

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	4.1.1.18
Description	Lysine decarboxylase.
Catalyzed reaction	L-lysine = cadaverine + CO(2).
Cofactor	Pyridoxal-phosphate.
Comments	-!- Also acts on 5'-hydroxy-L-lysine.
	In bacteria, the production of cadaverine by lysine decarboxylase appears to be a mechanism of resistance to acidic pH values. Several PDB structures (proteins from Arabidopsis and Thermus) are annotated as possible Lys decarboxylases, but the proteins are small and unrelated to the validated PLP-dependent enzymes with this activity.
Prosite	PROSITE; PDOC00585;
Organisms	-Bacteria -Plants
Family	4.1.1.18 (8)

Links	Enzyme (activities) 4.1.1.18 BRENDA (activities) 4.1.1.18 KEGG (pathways) 4.1.1.18 PLPMDB (PLP mutants) 4.1.1.18

References	Levine, M.; Progulske-Fox, A.; Denslow, N.D.; Farmerie, W.G.; Smith, D.M.; Swearingen, W.T.; Miller, F.C.; Liang, Z.; Roe, B.A.; Pan, H.Q. (2001) Identification of lysine decarboxylase as a mammalian cell growth inhibitor in Eikenella corrodens: possible role in periodontal disease Microb Pathog 30 179-92.. Lemonnier, M.; Lane, D. (1998) Expression of the second lysine decarboxylase gene of Escherichia coli Microbiology 144 751-60.. Fecker, L.F.; Beier, H.; Berlin, J. (1986) Cloning and characterization of a lysine decarboxylase gene from Hafnia alvei Mol Gen Genet 203 177-184. Articles on 4.1.1.18

last changed	2008/01/15 13:43

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