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B6db activities:
Description Lysine decarboxylase
Catalyzed reaction L-lysine = cadaverine + CO(2).
Cofactor Pyridoxal-phosphate.
Comments -!- Also acts on 5'-hydroxy-L-lysine.
In bacteria, the production of cadaverine by lysine decarboxylase appears to be a mechanism of resistance to acidic pH values.

Several PDB structures (proteins from Arabidopsis and Thermus) are annotated as possible Lys decarboxylases, but the proteins are small and unrelated to the validated PLP-dependent enzymes with this activity.

Prosite PROSITE; PDOC00585;
PDB 3N75; 3Q16; 6Q6I;
Organisms -Eubacteria -Plants


Links Enzyme (activities)
BRENDA (activities)
KEGG (pathways)
PLPMDB (PLP mutants)
 Han L, Yuan J, Ao X, Lin S, Han X, Ye H (2018) Biochemical Characterization and Phylogenetic Analysis of the Virulence Factor Lysine Decarboxylase From Vibrio vulnificus Front Microbiol 9 3082.

 Salomone-Stagni M, Bartho JD, Polsinelli I, Bellini D, Walsh MA, Demitri N, Benini S (2018) A complete structural characterization of the desferrioxamine E biosynthetic pathway from the fire blight pathogen Erwinia amylovora J Struct Biol S1047-8477 30029-7.

 Deng J, Gao H, Gao Z, Zhao H, Yang Y, Wu Q, Wu B, Jiang C (2017) Identification and molecular characterization of a metagenome-derived L-lysine decarboxylase gene from subtropical soil microorganisms PLoS One 12 e0185060.

 Xu B, Lei L, Zhu X, Zhou Y, Xiao Y (2017) Identification and characterization of L-lysine decarboxylase from Huperzia serrata and its role in the metabolic pathway of lycopodium alkaloid Phytochemistry 136 23-30.

 Bunsupa S, Hanada K, Maruyama A, Aoyagi K, Komatsu K, Ueno H, Yamashita M, Sasaki R, Oikawa A, Saito K, Yamazaki M. (2016) Molecular Evolution and Functional Characterization of a Bifunctional Decarboxylase Involved in Lycopodium Alkaloid Biosynthesis Plant Physiol 171 2432-44.

 Romano A, Trip H, Lolkema JS, Lucas PM (2013) Three-component lysine/ornithine decarboxylation system in Lactobacillus saerimneri 30a J Bacteriol 195 1249-54.

 Bunsupa S, Katayama K, Ikeura E, Oikawa A, Toyooka K, Saito K, Yamazaki M. (2012) Lysine decarboxylase catalyzes the first step of quinolizidine alkaloid biosynthesis and coevolved with alkaloid production in leguminosae. Plant Cell. 24 1202-16.

 Burrell M, Hanfrey CC, Kinch LN, Elliott KA, Michael AJ. (2012) Evolution of a novel lysine decarboxylase in siderophore biosynthesis. Mol Microbiol 485 1365-2958.

 Kanjee U1, Gutsche I, Alexopoulos E, Zhao B, El Bakkouri M, Thibault G, Liu K, Ramachandran S, Snider J, Pai EF, Houry WA. (2011) Linkage between the bacterial acid stress and stringent responses: the structure of the inducible lysine decarboxylase. EMBO J. 30 931-44.

 Chou HT, Hegazy M, Lu CD (2010) L-lysine catabolism is controlled by L-arginine and ArgR in Pseudomonas aeruginosa PAO1 J Bacteriol 192 5874-80.

 Sugawara A, Matsui D, Takahashi N, Yamada M, Asano Y, Isobe K (2010) Characterization of a pyridoxal-5'-phosphate-dependent l-lysine decarboxylase/oxidase from Burkholderia sp. AIU 395 J Biosci Bioeng 118 496-501.

 Levine, M.; Progulske-Fox, A.; Denslow, N.D.; Farmerie, W.G.; Smith, D.M.; Swearingen, W.T.; Miller, F.C.; Liang, Z.; Roe, B.A.; Pan, H.Q. (2001) Identification of lysine decarboxylase as a mammalian cell growth inhibitor in Eikenella corrodens: possible role in periodontal disease Microb Pathog 30 179-92.

 Lemonnier, M.; Lane, D. (1998) Expression of the second lysine decarboxylase gene of Escherichia coli Microbiology 144 751-60.

 Yamamoto, S.; Imamura, T.; Kusaba, K.; Shinoda, S. (1991) Purification and some properties of inducible lysine decarboxylase from Vibrio parahaemolyticus Chem Pharm Bull (Tokyo) 39 3067-70..

 Fecker, L.F.; Beier, H.; Berlin, J. (1986) Cloning and characterization of a lysine decarboxylase gene from Hafnia alvei Mol Gen Genet 203 177-184.

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last changed 2019/12/12 18:40

B6db activities