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B6db activities: 4.1.1.20

4.1.1.20
Description Diaminopimelate decarboxylase
Alternative names meso-diaminopimelate decarboxylase;
meso-diaminopimelic acid decarboxylase;
DAP decarboxylase;
DAPDC.
Catalyzed reaction Meso-2,6-diaminoheptanedioate = L-lysine + CO(2).
Cofactor Pyridoxal-phosphate.
Comments Bacteria have developed at least three different routes to synthesize lysine from aspartate, but in each of these routes lysine is ultimately produced by decarboxylating diaminopimelate (DAP), a metabolite that is also involved in peptidoglycan formation.

DAP is a symmetric molecule, containing two alpha carbons - one in configuration L, the other in configuration D. The enzyme selectively removes the carboxylate group from the latter, to generate L-lysine.
Thus, diaminopimelate decarboxylase is a rare case of PLP-dependent D-amino-acid decarboxylase, together with the strictly related D-ornithine/D-lysine decarboxylase (4.1.1.116).

Prosite PROSITE; PDOC00685;
PDB 1HKW; 1TWI; 5X7M;
Organisms -Eubacteria -Archea -Plants
 
 
Links Enzyme (activities) 4.1.1.20
BRENDA (activities) 4.1.1.20
KEGG (pathways) 4.1.1.20
PLPMDB (PLP mutants) 4.1.1.20
 
References Articles on 4.1.1.20
 
last changed 2019/05/29 09:37

B6db activities