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B6db activities:
Description Diaminopimelate decarboxylase
Alternative names meso-diaminopimelate decarboxylase;
meso-diaminopimelic acid decarboxylase;
DAP decarboxylase;
Catalyzed reaction Meso-2,6-diaminoheptanedioate = L-lysine + CO(2).
Cofactor Pyridoxal-phosphate.
Comments Bacteria have developed at least three different routes to synthesize lysine from aspartate, but in each of these routes lysine is ultimately produced by decarboxylating diaminopimelate (DAP), a metabolite that is also involved in peptidoglycan formation.

DAP is a symmetric molecule, containing two alpha carbons - one in configuration L, the other in configuration D. The enzyme selectively removes the carboxylate group from the latter, to generate L-lysine.
Thus, diaminopimelate decarboxylase is a rare case of PLP-dependent D-amino-acid decarboxylase, together with the strictly related D-ornithine/D-lysine decarboxylase (

Prosite PROSITE; PDOC00685;
Organisms -Eubacteria -Archea -Plants
Links Enzyme (activities)
BRENDA (activities)
KEGG (pathways)
PLPMDB (PLP mutants)
References Articles on
last changed 2019/05/29 09:37

B6db activities