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B6db activities:
Description Tyrosine decarboxylase
Catalyzed reaction L-tyrosine = tyramine + CO(2).
Cofactor Pyridoxal-phosphate.
Comments -!- The bacterial enzyme also acts on 3-hydroxytyrosine and, more slowly, on 3-hydroxyphenylalanine.
This entry does not include plant enzymes with tyrosine decarboxylase activity, which have been included into EC (Aromatic amino acid decarboxylase).
Prosite PROSITE; PDOC00329;
Organisms -Eubacteria -Archea -Plants


Links Enzyme (activities)
BRENDA (activities)
KEGG (pathways)
PLPMDB (PLP mutants)
 Chellam Gayathri S, Manoj N (2019) Structural insights into the mechanism of internal aldimine formation and catalytic loop dynamics in an archaeal Group II decarboxylase J Struct Biol 208 137-151.

 Zhu H, Xu G, Zhang K, Kong X, Han R, Zhou J, Ni Y (2016) Crystal structure of tyrosine decarboxylase and identification of key residues involved in conformational swing and substrate binding Sci Rep 6 27779.

 Arena ME, Fiocco D, Manca de Nadra MC, Pardo I, Spano G. (2007) Characterization of a Lactobacillus plantarum strain able to produce tyramine and partial cloning of a putative tyrosine decarboxylase gene Curr Microbiol 55 205-10.

 Marcobal A, de las Rivas B, Muñoz R. (2006) First genetic characterization of a bacterial beta-phenylethylamine biosynthetic enzyme in Enterococcus faecium RM58 FEMS Microbiol Lett 258 144-9.

 Kezmarsky, N.D; Xu, H.; Graham, D.E.; White, R.H. (2005) Identification and characterization of a l-tyrosine decarboxylase in Methanocaldococcus jannaschii Biochim Biophys Acta 1722 175-182.

 Fernández M, Linares DM, Alvarez MA. (2004) Sequencing of the tyrosine decarboxylase cluster of Lactococcus lactis IPLA 655 and the development of a PCR method for detecting tyrosine decarboxylating lactic acid bacteria J Food Prot 67 2521-9.

 Connil, N.; Le Breton, Y.; Dousset, X.; Auffray, Y.; Rince, A.; Prevost, H. (2002) Identification of the Enterococcus faecalis tyrosine decarboxylase operon involved in tyramine production Appl Environ Microbiol 68 3537-44.

 Lucas, P.; Lonvaud-Funel, A. (2002) Purification and partial gene sequence of the tyrosine decarboxylase of Lactobacillus brevis IOEB 9809 FEMS Microbiol Lett 211 85-9.

Articles on
last changed 2019/06/21 13:09

B6db activities