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B6db activities:
Description Carboxynorspermidine decarboxylase
Alternative names nspC;
Carboxyspermidine decarboxylase.
Catalyzed reaction Carboxynorspermidine <=> bis(3-aminopropyl)amine + CO(2)
Carboxyspermidine <=> spermidine + CO(2)
Cofactor Pyridoxal-phosphate
Comments Part of a bacterial polyamine biosynthesis pathway. The enzyme is essential for biofilm formation in the bacterium Vibrio cholerae. The enzyme from Campylobacter jejuni only produces spermidine in vivo even though it shows activity with carboxynorspermidine in vitro.
This is the last enzyme in the biosynthesis of norspermidine, a polyamine similar to the more common spermidine.
Norspermidine has been found to occur naturally in some species of bacteria as well as in plants.
PDB 3N29;
Organisms -Eubacteria

Family (0)
Links Enzyme (activities)
BRENDA (activities)
KEGG (pathways)
PLPMDB (PLP mutants)
References Articles on
last changed 2014/03/20 13:20

B6db activities