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B6db activities:
Description Low-specificity L-threonine aldolase
Alternative names L-threonine/L-allo-threonine acetaldehyde-lyase (glycine-forming);
Catalyzed reaction L-threonine = glycine + acetaldehyde L-allo-threonine = glycine + acetaldehyde
Cofactor Pyridoxal-phosphate.
Comments Requires pyridoxal phosphate. The low-specificity L-threonine aldolase can act on both L-threonine and L-allo-threonine. The enzyme from Escherichia coli can also act on L-threo-phenylserine and L-erythro-phenylserine. The enzyme can also catalyse the aldol condensation of glycolaldehyde and glycine to form 4-hydroxy-L-threonine, an intermediate of pyridoxal phosphate biosynthesis. Different from EC, L-threonine aldolase, and EC, L-allo-threonine aldolase.
Organisms -Eubacteria
Links Enzyme (activities)
BRENDA (activities)
KEGG (pathways)
PLPMDB (PLP mutants)
 Liu, J. Q.; Ito, S.; Dairi, T.; Itoh, N.; Kataoka, M.; Shimizu, S.; Yamada, H. (1998) Gene cloning, nucleotide sequencing, and purification and characterization of the low-specificity L-threonine aldolase from Pseudomonas sp. strain NCIMB 10558 Appl Environ Microbiol 64 549-54.

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last changed 2019/06/21 13:14

B6db activities