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B6db activities: 4.1.2.5

4.1.2.5
Description Threonine aldolase
Alternative names L-Threonine aldolase;
L-threonine acetaldehyde-lyase.
Catalyzed reaction L-threonine = glycine + acetaldehyde.
Cofactor Pyridoxal-phosphate.
Threonine aldolase is responsible of one of the three pathways of L-threonine degradation in bacteria, fungi and plants.
The importance of this pathway is marginal in metazoa, and some animals seem to completely lack the activity.

L-threonine aldolases can be subdivided into three sub-types: L-specific threonine aldolase (LTA), which preferably cleaves plain L-threonine; L-allo-threonine aldolase (LalloTA), which cleaves L-allo-threonine; and low specificity threonine aldolase (LlowTA) which accepts both L-Thr and L-allo-Thr as substrates.

PDB 1JG8;
Organisms -Eubacteria -Archea -Fungi -Metazoa
 
 
Links Enzyme (activities) 4.1.2.5
BRENDA (activities) 4.1.2.5
KEGG (pathways) 4.1.2.5
PLPMDB (PLP mutants) 4.1.2.5
 
References Articles on 4.1.2.5
 
last changed 2019/06/20 11:24

B6db activities