B6db activities : 4_2_3

	Activities \| Families \| Sequences \| Fold types \| References \| Help


	4.2.3.134
Description	5-phosphonooxy-L-lysine phospho-lyase
Alternative names	5-phosphohydroxy-L-lysine ammoniophospholyase; (5R)-5-phosphonooxy-L-lysine phosphate-lyase (deaminating;(S)-2-amino-6-oxohexanoate-forming)
Catalyzed reaction	(5R)-5-phosphonooxy-L-lysine + H2O = (S)-2-amino-6-oxohexanoate + NH3 + phosphate
Cofactor	Pyridoxal-phosphate.
Comments	A pyridoxal-phosphate protein. Has no activity with phosphoethanolamine (cf. EC 4.2.3.2, ethanolamine-phosphate phospho-lyase).
Organisms	-Metazoa -Human
Family	4.2.3.134 (0)

Links	Enzyme (activities) 4.2.3.134 BRENDA (activities) 4.2.3.134 KEGG (pathways) 4.2.3.134 PLPMDB (PLP mutants) 4.2.3.134

References	Veiga-da-Cunha, M., Hadi, F., Balligand, T., Stroobant, V. and Van Schaftingen, E. (2012) Molecular identification of hydroxylysine kinase and of ammoniophospholyases acting on 5-phosphohydroxy-L-lysine and phosphoethanolamine. J. Biol. Chem. 287 7246-7255. Tsai, C.H. and Henderson, L.M. (1974) Degradation of O-phosphohydroxylysine by rat liver. Purification of the phospho-lyase. J. Biol. Chem. 249 5784-5789. Articles on 4.2.3.134

last changed	2017/06/23 13:03

Family