B6db activities : 4_2_3

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	4.2.3.2
Description	Ethanolamine-phosphate phospho-lyase
Catalyzed reaction	Ethanolamine phosphate + H(2)O = acetaldehyde + NH(3) + phosphate.
Cofactor	Pyridoxal-phosphate.
Comments	-!- Also acts on D- (or L)-1-aminopropan-2-ol O-phosphate. -!- Formerly EC 4.2.99.7.
PDB	5G4J;
Organisms	-Eubacteria -Metazoa -Human
Family	4.2.3.2 (0)

Links	Enzyme (activities) 4.2.3.2 BRENDA (activities) 4.2.3.2 KEGG (pathways) 4.2.3.2 PLPMDB (PLP mutants) 4.2.3.2

References	Cuetos A, Steffen-Munsberg F, Mangas Sanchez J, Frese A, Bornscheuer UT, Höhne M, Grogan G (2016) Structural Basis for Phospholyase Activity of a Class III Transaminase Homologue Chembiochem 17 2308-2311. Schiroli, D.; Cirrincione, S.; Donini, S.; Peracchi, A. (2013) Strict reaction and substrate specificity of AGXT2L1, the human O-phosphoethanolamine phospho-lyase IUBMB Life 65 645-50. Veiga-da-Cunha, M., Hadi, F., Balligand, T., Stroobant, V. and Van Schaftingen, E. (2012) Molecular identification of hydroxylysine kinase and of ammoniophospholyases acting on 5-phosphohydroxy-L-lysine and phosphoethanolamine. J. Biol. Chem. 287 7246-7255. Fleshood, H. L.; Pitot, H. C. (1970) The metabolism of O-phosphorylethanolamine in animal tissues. I. O- phosphorylethanolamine phospho-lyase: partial purification and characterization J Biol Chem 245 4414-20. Articles on 4.2.3.2

last changed	2019/02/13 15:55

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