Activities | Families | Sequences | Fold types | References | Help
B6db activities:
Description D-serine ammonia-lyase
Alternative names D-serine dehydratase;
D-serine dehydrase;
D-hydroxy amino acid dehydratase;
D-serine hydrolase;
D-serine dehydratase (deaminating);
D-serine deaminase;
D-serine hydro-lyase (deaminating).
Catalyzed reaction D-serine = pyruvate + NH(3).
Cofactor Pyridoxal-phosphate or Zn(II) ions plus pyridoxal-phosphate.
Comments Also acts, slowly, on D-threonine.
The reaction catalyzed probably involves initial elimination of water (hence the enzyme's original classification as EC,followed by isomerization and hydrolysis of the product with C-N bond breakage.
Formerly EC
The enzyme from E. coli is a fold-type II protein, whereas the D-ser dehydratase from S. cerevisiae is a fold-type III enzyme and employs zinc ions as cofactors, in addition to pyridoxal phosphate.
PDB 3SS7; 3SS9;
Organisms -Eubacteria -Fungi -Metazoa


Links Enzyme (activities)
BRENDA (activities)
KEGG (pathways)
PLPMDB (PLP mutants)
References Articles on
last changed 2019/06/20 13:01

B6db activities