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Description Threo-3-hydroxy-D-aspartate ammonia-lyase
Alternative names D-threo-3-hydroxyaspartate dehydratase;
threo-3-hydroxy-D-aspartate ammonia-lyase (oxaloacetate-forming)
Catalyzed reaction threo-3-hydroxy-D-aspartate = oxaloacetate + NH3
Cofactor Pyridoxal-phosphate and Mn(II).
Comments A pyridoxal-phosphate protein. The enzyme, purified from the bacterium Delftia sp. HT23, also has activity against L-threo-3-hydroxyaspartate, L-erythro-3-hydroxyaspartate, and D-serine.
Different from EC, erythro-3-hydroxy-L-aspartate ammonia-lyase and EC4.3.1.16, threo-3-hydroxy-L-aspartate ammonia-lyase.

Requires a divalent cation such as Mn2+, Co2+ or Ni2+.

D-threo-3-Hydroxyaspartate dehydratase (D-THA DH) isolated from the soil bacterium Delftia sp. The amino-acid sequence of D-THA DH shows significant similarity to that of two eukaryotic D-serine dehydratases derived from Saccharomyces cerevisiae and chicken kidney. D-THA DH is classified into the fold-type III group of pyridoxal enzymes and is the first example of a fold-type III dehydratase derived from a prokaryote.
Organisms -Eubacteria

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last changed 2017/09/06 11:22

B6db activities