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B6db activities: 4.4.1.14

4.4.1.14
Description 1-aminocyclopropane-1-carboxylate synthase
Alternative names 1-aminocyclopropane-1-carboxylic acid synthase;
Aminocyclopropanecarboxylate synthase;
ACC synthase.
Catalyzed reaction S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + methylthioadenosine.
Cofactor Pyridoxal-phosphate.
Comments -!- Catalyzes an alpha, gamma-elimination.
In plants, the enzyme carries out the rate-limiting step in the ethylene biosynthetic pathway.

The only validated bacterial enzyme (from a Streptomyces species) is involved in the biosynthesis of the secondary metabolites guangnanmycins.

Prosite PROSITE; PDOC00098;
PDB 1IAY; 1IAX; 1B8G;
Organisms -Eubacteria -Plants -Fungi
 

Family 

 
Links Enzyme (activities) 4.4.1.14
BRENDA (activities) 4.4.1.14
KEGG (pathways) 4.4.1.14
PLPMDB (PLP mutants) 4.4.1.14
 
References
 Lee JH, Kim YC, Choi D, Han JH, Jung Y, Lee S (2018) RNA expression, protein activity, and interactions in the ACC synthase gene family in cucumber (Cucumis sativus L.) Hortic Environ Biotechnol 59 81.

 Xu Z, Pan G, Zhou H, Shen B. (2018) Discovery and Characterization of 1-Aminocyclopropane-1-carboxylic Acid Synthase of Bacterial Origin J Am Chem Soc 140 1695761.

 Wang D, Fan J, Ranu RS. (2004) Cloning and expression of 1-aminocyclopropane-1-carboxylate synthase cDNA from rosa (Rosa x hybrida) Plant Cell Rep 22 422-9.

 Kakuta, Y.; Igarashi, T.; Murakami, T.; Ito, H.; Matsui, H.; Honma, M. (2001) 1-Aminocyclopropane-1-carboxylate synthase of Penicillium citrinum: primary structure and expression in Escherichia coli and Saccharomyces cerevisiae Biosci Biotechnol Biochem 65 1511-8.

 Capitani G.; Hohenester, E.; Feng, L.; Storici, P.; Kirsch, J.F.; Jansonius, J.N. (1999) Structure of 1-aminocyclopropane-1-carboxylate synthase, a key enzyme in the biosynthesis of the plant hormone ethylene J Mol Biol 294 745-56.

 Sato, T.; Oeller, P. W.; Keller, J. A.; Theologis, A. (1991) The 1-aminocyclopropane-1-carboxylate synthase of Cucurbita. Purification, properties, expression in Escherichia coli, and primary structure determination by DNA sequence analysis J Biol Chem 266 3752-9.

 Van der Straeten, D.; Van Wiemeersch, L.; Goodman, H. M.; Van Montagu, M. (1990) Cloning and sequence of two different cDNAs encoding 1-aminocyclopropane-1-carboxylate synthase in tomato Proc Natl Acad Sci U S A 87 4859-63.

Articles on 4.4.1.14
 
last changed 2019/05/28 14:30

B6db activities