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B6db activities:
Description L-cysteine desulfidase
Alternative names L-cysteine desulfhydrase;
C-S lyase (ambiguous).
Catalyzed reaction L-Cysteine + H(2)O = pyruvate + H(2)S + NH(3)
Cofactor Pyridoxal-phosphate or [4Fe-4S] cluster.
Comments It cleaves a carbon-sulfur bound releasing sulfide and the unstable enamine product 2-aminoprop-2-enoate that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia. The reaction can be catalysed by other pyridoxal-phosphate proteins (cf. EC, cystathionine γ-lyase).
The enzyme from the archaeon Methanocaldococcus jannaschii contains a [4Fe-4S] cluster instead of PLP.
The validated PLP-dependent enzymes that catalyze this reaction also show cystathionine beta-lyase activity (E.C. and sometimes methionine gamma-lyase activity (
Organisms -Eubacteria -Archea
Links Enzyme (activities)
BRENDA (activities)
KEGG (pathways)
PLPMDB (PLP mutants)
References Articles on
last changed 2019/06/20 13:29

B6db activities