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B6db activities: 4.4.1.9

4.4.1.9
Description L-3-cyanoalanine synthase
Alternative names Beta-cyanoalanine synthase;
Beta-cyano-L-alanine synthase.
Catalyzed reaction L-cysteine + cyanide = H(2)S + L-3-cyanoalanine.
Cofactor Pyridoxal-phosphate.
Comments Enzymes with this activity are strictly related to Cysteine Synthase (EC 2.5.1.47) both from a mechanistic and from a phylogenetic viewpoint.

In particular, family a is composed only of plant enzymes, which appear to be mitochondrial isozymes of cysteine synthase.

Family b contains enzymes from insects, useful for cyanide detoxification and apparently acquired from bacteria through horizontal gene transfer.

One cyanoalanine synthase from bacteria (Bacillus stearothermophilus) has also been cloned and characterized, but this enzyme is in fact tenfold more active as a cysteine synthase, and has been included in the 2.5.1.47 family.

PDB 3VBE;
Organisms -Eubacteria -Plants -Metazoa
 
 
Links Enzyme (activities) 4.4.1.9
BRENDA (activities) 4.4.1.9
KEGG (pathways) 4.4.1.9
PLPMDB (PLP mutants) 4.4.1.9
 
References Articles on 4.4.1.9
 
last changed 2019/06/20 12:01

B6db activities