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B6db activities:
Description Aspartate racemase.
Catalyzed reaction L-aspartate = D-aspartate
Cofactor Pyridoxal-phosphate or none
Aspartate racemases from mammals are fold-type I proteins (and have been grouped in family whereas aspartate racemases from mollusks are fold-type II (family

Known aspartate racemases from eubacteria are not PLP-dependent. In Archaea, PLP-dependent enzymes have been isolateed but not characterized at the molecular level.

Prosite PDOC00714
Organisms -Archea -Metazoa


Links Enzyme (activities)
BRENDA (activities)
KEGG (pathways)
PLPMDB (PLP mutants)
 Kim PM, Duan X, Huang AS, Liu CY, Ming GL, Song H, Snyder SH (2010) Aspartate racemase, generating neuronal D-aspartate, regulates adult neurogenesis Proc Natl Acad Sci U S A 107 3175-9.

 Abe K, Takahashi S, Muroki Y, Kera Y, Yamada RH. (2006) Cloning and expression of the pyridoxal 5'-phosphate-dependent aspartate racemase gene from the bivalve mollusk Scapharca broughtonii and characterization of the recombinant enzyme J Biochem 139 235-44.

 Shibata, K.; Watanabe, T.; Yoshikawa, H.; Abe, K.; Takahashi, S.; Kera, Y.; Yamada, R. (2003) Purification and characterization of aspartate racemase from the bivalve mollusk Scapharca broughtonii Comp Biochem Physiol B Biochem Mol Biol 134 307-314.

 Long, Z.; Lee, J. A.; Okamoto, T.; Sekine, M.; Nimura, N.; Imai, K.; Yohda, M.; Maruyama, T.; Sumi, M.; Kamo, N.; Yamagishi, A.; Oshima, T.; Homma, H. (2001) Occurrence of D-Amino Acids and a pyridoxal 5'-phosphate-dependent aspartate racemase in the acidothermophilic archaeon, Thermoplasma acidophilum Biochem Biophys Res Commun 281 317-21.

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last changed 2010/06/14 11:10

B6db activities