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B6db activities:
Description Glutamate-1-semialdehyde 2,1-aminomutase
Alternative names Glutamate-1-semialdehyde aminotransferase;
HemL (gene name);
Catalyzed reaction (S)-4-amino-5-oxopentanoate = 5-aminolevulinate.
Cofactor Pyridoxal-phosphate or Pyridoxamine-phosphate.
Glutamate-1-semialdehyde 2,1-aminomutase is the second enzyme in the tetrapyrrole biosynthesis pathway found in most bacteria, in archaea and in plants (the first enzyme in the pathway is a most unusual glutamyl-tRNA reductase).
The enzyme has therefore paramount importance in the biosynthesis of compounds such as heme and chlorophyll.
Prosite PROSITE; PDOC00519;
Organisms -Eubacteria -Archea -Plants

Family (0)
Links Enzyme (activities)
BRENDA (activities)
KEGG (pathways)
PLPMDB (PLP mutants)
 Nardella C, Boi D, di Salvo ML, Barile A, Stetefeld J, Tramonti A, Contestabile R (2019) Isolation of a Complex Formed Between Acinetobacter baumannii HemA and HemL, Key Enzymes of Tetrapyrroles Biosynthesis Front Mol Biosci 6 6.

 Song Y, Pu H, Jiang T, Zhang L, Ouyang M (2016) Crystal structure of glutamate-1-semialdehyde-2,1-aminomutase from Arabidopsis thaliana Acta Crystallogr F Struct Biol Commun. 72 448-56.

 Schulze JO, Schubert WD, Moser J, Jahn D, Heinz DW. (2006) Evolutionary relationship between initial enzymes of tetrapyrrole biosynthesis J Mol Biol 358 1212-20.

 Atteia A, van Lis R, Beale SI. (2005) Enzymes of the heme biosynthetic pathway in the nonphotosynthetic alga Polytomella sp. Eukaryot Cell 4 2087-97.

 Tsang, E.W.; Hu Z.; Chang, Q.; McGregor, D.I.; Keller, W.A. (2003) Expression of a Brassica napus glutamate 1-semialdehyde aminotransferase in Escherichia coli and characterization of the recombinant protein Protein Expr Purif 29 193-201..

 Hennig, M.; Grimm, B.; Contestabile, R.; John, R. A.; Jansonius, J. N. (1997) Crystal structure of glutamate-1-semialdehyde aminomutase: an alpha2-dimeric vitamin B6-dependent enzyme with asymmetry in structure and active site reactivity Proc Natl Acad Sci U S A 94 4866-71.

 Palmieri, G.; Di Palo, M.; Scaloni, A.; Orru, S.; Marino, G.; Sannia, G. (1996) Glutamate-1-semialdehyde aminotransferase from Sulfolobus solfataricus Biochem J 320 541-5.

 Murakami, K.; Hashimoto, Y.; Murooka, Y. (1993) Cloning and characterization of the gene encoding glutamate 1-semialdehyde 2,1-aminomutase, which is involved in delta-aminolevulinic acid synthesis in Propionibacterium freudenreichii Appl Environ Microbiol 59 347-50.

 Murakami, K.; Korbsrisate, S.; Asahara, N.; Hashimoto, Y.; Murooka, Y. (1993) Cloning and characterization of the glutamate 1-semialdehyde aminomutase gene from Xanthomonas campestris pv. phaseoli Appl Microbiol Biotechnol 38 502-6..

 Sangwan, I.; O'Brian, M. R. (1993) Expression of the soybean (Glycine max) glutamate 1-semialdehyde aminotransferase gene in symbiotic root nodules Plant Physiol 102 829-34.

 Ilag, L. L.; Jahn, D.; Eggertsson, G.; Soll, D. (1991) The Escherichia coli hemL gene encodes glutamate 1-semialdehyde aminotransferase J Bacteriol 173 3408-13.

 Elliott, T.; Avissar, Y. J.; Rhie, G. E.; Beale, S. I. (1990) Cloning and sequence of the Salmonella typhimurium hemL gene and identification of the missing enzyme in hemL mutants as glutamate-1-semialdehyde aminotransferase J Bacteriol 172 7071-84.

 Grimm, B. (1990) Primary structure of a key enzyme in plant tetrapyrrole synthesis: glutamate 1-semialdehyde aminotransferase Proc Natl Acad Sci U S A 87 4169-73..

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last changed 2019/06/20 13:03

B6db activities