Activities | Families | Sequences | Fold types | References | Help
B6db activities: cuab

Description Curvulamine intermediate synthase (2.3.1.-)
Alternative names cuaB (gene name);
Catalyzed reaction 3-oxo-4-hexenoyl-[acyl-carrier protein] + alanine + O(2) = [acyl-carrier protein] + 2-hydroxy-2-methyl-5-[(1E,3E)-penta-1,3-dien-1-yl]-1,2-dihydro-3H-pyrrol-3-one + CO(2) + H(2)O(2).
Cofactor Pyridoxal phosphate.
Comments The enzyme catalyzes an intermediate step in the biosynthesis of the indolizidine alkaloid Curvulamine.

CuaB acts on the highly reduced acyl chain produced by a polyketide synthase complex, releasing this chain from the acyl carrier protein (ACP) of the complex.
Such a relaease entails a decarboxylative claisen condensation between L-alanine and acyl-S-ACP, followed by the reaction of the PLP-bound decarboxylated intermediate with molecular oxygen.

Organisms -Fungi


cuab (0)
Links Enzyme (activities) cuab
BRENDA (activities) cuab
KEGG (pathways) cuab
PLPMDB (PLP mutants) cuab
 Dai GZ, Han WB, Mei YN, Xu K, Jiao RH, Ge HM, Tan RX (2020) Pyridoxal-5'-phosphate-dependent bifunctional enzyme catalyzed biosynthesis of indolizidine alkaloids in fungi Proc Natl Acad Sci U S A. 117 1174-1180.

Articles on cuab
last changed 2019/12/28 16:41

B6db activities