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B6db activities: cystine.lyase

Description Cystine lyase (4.4.1.-)
Alternative names cystine C-S lyase;
Catalyzed reaction L-Cystine + H(2)O = cysteine persulfide + pyruvate + NH(3)
Cofactor Pyridoxal-phosphate.
Comments Different from cysteine desulfurase (EC, in that the favorite substrate is cystine and the product persulfide is not protein-bound.

The reaction is carried out also by cystathionine beta-lyase (EC

Cystine lyase enzymes have been described in cyanobacteria (C-DES) and in plants.

Organisms -Eubacteria -Plants


Links Enzyme (activities) cystine_lyase
BRENDA (activities) cystine_lyase
KEGG (pathways) cystine_lyase
PLPMDB (PLP mutants) cystine_lyase
 Munt O, Prüfer D, Schulze Gronover C. (2013) A novel C-S lyase from the latex-producing plant Taraxacum brevicorniculatum displays alanine aminotransferase and l-cystine lyase activity. J Plant Physiol. 170 33-40.

 Kessler D. (2006) Slr0077 of Synechocystis has cysteine desulfurase as well as cystine lyase activity Biochem Biophys Res Commun 320 571-7.

 Jones, P.R.; Manabe, T.; Awazuhara, M.; Saito, K. (2003) A new member of plant CS-lyases. A cystine lyase from Arabidopsis thaliana J Biol Chem 278 10291-6.

 Kaiser, J.T.; Bruno, S.; Clausen, T.; Huber, R.; Schiaretti, F.; Mozzarelli, A.; Kessler, D. (2003) Snapshots of the cystine lyase C-DES during catalysis. Studies in solution and in the crystalline state J Biol Chem 278 357-65.

 Lang, T.; Kessler, D. (1999) Evidence for cysteine persulfide as reaction product of L-Cyst(e)ine C-S-lyase (C-DES) from Synechocystis. Analyses using cystine analogues and recombinant C-DES J Biol Chem 274 189-95.

Articles on cystine.lyase
last changed 2010/01/27 18:00

B6db activities