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B6db activities: egte

Description Hercynylcysteine sulfoxide lyase (4.4.1.-)
Alternative names EgtE
Catalyzed reaction hercynylcysteine sulfoxide = ergothioneine + pyruvate + NH3
Cofactor Pyridoxal phosphate.
Comments Ergothioneine is a thiourea derivative of histidine, containing a sulfur atom on the imidazole ring. It is produced by some fungi and bacteria, but it has also been isolated from animal tissues.
In mycobacteria, EgtE has been suggested to catalyze the last step of ergothioneine biosynthesis. The reaction is at the moment hypothetical.
Organisms -Bacteria


egte (5)
Links Enzyme (activities) egte
BRENDA (activities) egte
KEGG (pathways) egte
PLPMDB (PLP mutants) egte
 Seebeck, F.P. (2010) In vitro reconstitution of mycobacterial ergothioneine biosynthesis J Am Chem Soc 132 6632-3.

Articles on egte
last changed 2010/06/14 16:22

B6db activities