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B6db activities: fum8
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fum8
Description Fumonisin B1 synthase (2.3.1.-)
Alternative names Polyketide Chain Releasing enzyme;
alpha-Oxoamine Synthase (ambiguous).
Catalyzed reaction polyketide-[acyl-carrier protein] + alanine = [acyl-carrier protein] + fumonisin B1 + CO(2).
Cofactor Pyridoxal phosphate.
Comments The enzyme catalyzes the last step in the biosynthesis of the polyketide-based mycotoxin Fumonisin B1.

Fum8 acts on the highly reduced acyl chain produced by a polyketide synthase complex, releasing this chain from the acyl carrier protein (ACP) of the complex. Such a relaease entails a decarboxylative condensation between L-alanine and acyl-S-ACP.
Organisms -Fungi
 

Family 
fum8 (0)
 
Links Enzyme (activities) fum8
BRENDA (activities) fum8
KEGG (pathways) fum8
PLPMDB (PLP mutants) fum8
 
References
 Gerber R, Lou L, Du L. (2009) A PLP-Dependent Polyketide Chain Releasing Mechanism in the Biosynthesis of Mycotoxin Fumonisins in Fusarium verticillioides J Am Chem Soc 131 3148–3149.

Articles on fum8
 
last changed 2009/07/07 16:08

B6db activities