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B6db activities: gabt1

Description D-fructose-6-phosphate-L-glutamate transaminase (2.6.1.-)
Catalyzed reaction keto-D-fructose 6-phosphate + L-glutamate = 2-amino-2-deoxy-mannitol-6-phosphate + 2-oxoglutarate.
Cofactor Pyridoxal phosphate
Comments The enzyme gabt1 catalyzes the first step in the biosynthesis of the azasugar mannojirimycin. This compound is an intermediate in the biosynthesis of the nojirimycins, which are glycosidase inhibitors.
Organisms -Eubacteria


gabt1 (0)
Links Enzyme (activities) gabt1
BRENDA (activities) gabt1
KEGG (pathways) gabt1
PLPMDB (PLP mutants) gabt1
 Arciola JM, Horenstein NA. (2018) Characterization of the PLP-dependent transaminase initiating azasugar biosynthesis Biochem J 475 2241-2256.

 Clark LF, Johnson JV, Horenstein NA (2011) Identification of a gene cluster that initiates azasugar biosynthesis in Bacillus amyloliquefaciens. Chembiochem 12 2147-50.

Articles on gabt1
last changed 2019/06/20 18:14

B6db activities