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B6db activities: glii

Description Twin carbon-sulfur lyase (4.4.1.-)
Alternative names GliI (gene name);
carbon-sulfate lyase;
Catalyzed reaction A bis(cysteine) S-conjugate + H(2)O = reduced (dithiol) gliotoxin + 2 NH(3) + 2 pyruvate
Cofactor Pyridoxal-phosphate
Involved in the fungal production of gliotoxin. The mechanism of the enzyme is believed to involve two essentially simultaneous beta-elimination reactions occurring at the two cysteine moyeties of the substrate.
Organisms -Fungi


glii (0)
Links Enzyme (activities) glii
BRENDA (activities) glii
KEGG (pathways) glii
PLPMDB (PLP mutants) glii
 Scharf DH, Chankhamjon P, Scherlach K, Heinekamp T, Roth M, Brakhage AA, Hertweck C. (2012) Epidithiol formation by an unprecedented twin carbon-sulfur lyase in the gliotoxin pathway. Angew Chem Int Ed Engl 51 10064-8.

Articles on glii
last changed 2018/04/16 17:11

B6db activities