B6db activities : l-lysine_2-aminotransferase

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	l-lysine_2-aminotransferase
Description	L-lysine 2-aminotransferase (2.6.1.-)
Alternative names	BomE (gene name);
Catalyzed reaction	L-lysine + pyruvate = 2-oxo-6-aminohexanoate + L-alanine.
Cofactor	Pyridoxal-phosphate.
	Other ketoacids can function as acceptors of the amino group. Apparently, the 2-oxo-6-aminohexanoate product readily rearranges to a cyclic, dehydrated form, piperideine-2-carboxylate, which is a precursor in the biosynthesis of some antibiotics.
Organisms	-Eubacteria
Family	l-lysine_2-aminotransferase_a (0) l-lysine_2-aminotransferase_b (0)

Links	Enzyme (activities) l-lysine_2-aminotransferase BRENDA (activities) l-lysine_2-aminotransferase KEGG (pathways) l-lysine_2-aminotransferase PLPMDB (PLP mutants) l-lysine_2-aminotransferase

References	Yun X, Zhang Q, Lv M, Deng H, Deng Z, Yu Y. (2019) In vitro reconstitution of the biosynthetic pathway of 3-hydroxypicolinic acid Org Biomol Chem 17 454-460. Xu B, Fan Z, Lei Y, Ping Y, Jaisi A, Xiao Y (2018) Insights into Pipecolic Acid Biosynthesis in Huperzia serrata Org Lett 20 2195-2198. Lv M, Zhao J, Deng Z, Yu Y (2015) Characterization of the Biosynthetic Gene Cluster for Benzoxazole Antibiotics A33853 Reveals Unusual Assembly Logic Chem Biol 22 1313-24. Namwat, W.; Kinoshita, H.; Nihira, T. (2002) Identification by heterologous expression and gene disruption of VisA as L-lysine 2-aminotransferase essential for virginiamycin S biosynthesis in Streptomyces virginiae J Bacteriol 184 4811-8. Bruntner, C.; Bormann, C. (1998) The Streptomyces tendae Tu901 L-lysine 2-aminotransferase catalyzes the initial reaction in nikkomycin D biosynthesis Eur J Biochem 254 347-55. Articles on l-lysine.2-aminotransferase

last changed	2018/02/16 18:43

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