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B6db activities: lipo

Description L-methionine--uridine-5'-aldehyde aminotransferase (2.6.1.-)
Alternative names LipO (gene name);
Pac5 (gene name);
Mur20 (gene name);
Catalyzed reaction L-methionine + uridine-5'-aldehyde = 4-methylthio-2-oxobutanoate + 5'-aminouridine.
Cofactor Pyridoxal phosphate
Comments Involved in the biosynthesis of nucleoside antibiotics such as liposidomycin and in peptidoglycan cell wall biosynthesis.

These aminotransferases can apparently use different amino group donors, but the enzymes from Streptomyces sp. SANK 60405 and Streptomyces roseoverticillatus (aka Streptoverticillium fervens) reportedly use L-methionine as the preferred amino group donor.

Organisms -Eubacteria


lipo (0)
Links Enzyme (activities) lipo
BRENDA (activities) lipo
KEGG (pathways) lipo
PLPMDB (PLP mutants) lipo
 Cui Z, Liu X, Overbay J, Cai W, Wang X, Lemke A, Wiegmann D, Niro G, Thorson JS, Ducho C, Van Lanen SG (2018) Enzymatic Synthesis of the Ribosylated Glycyl-Uridine Disaccharide Core of Peptidyl Nucleoside Antibiotics J Org Chem 83 7239-7249.

 Hiratsuka T, Suzuki H, Kariya R, Seo T, Minami A, Oikawa H. (2014) Biosynthesis of the structurally unique polycyclopropanated polyketide-nucleoside hybrid jawsamycin (FR-900848). Angew Chem Int Ed Engl. 53 5423-6.

 Chi X, Pahari P, Nonaka K, Van Lanen SG. (2011) Biosynthetic origin and mechanism of formation of the aminoribosyl moiety of peptidyl nucleoside antibiotics. J Am Chem Soc. 133 14452-9.

 Ragab AE, Grüschow S, Tromans DR, Goss RJ (2011) Biogenesis of the unique 4',5'-dehydronucleoside of the uridyl peptide antibiotic pacidamycin J Am Chem Soc. 133 15288-91.

Articles on lipo
last changed 2019/12/28 20:20

B6db activities