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B6db activities: lmbs

Description GDP-D-α-D-lincosamide aminotransferase (2.6.1.-)
Alternative names CcbS (gene name);
LmbS (gene name)
Catalyzed reaction GDP-D-α-D-lincosamide + 2-oxoglutarate <=> GDP-6-oxo 6(1-hydroxyethyl)galactose + glutamate
Cofactor Pyridoxal phosphate.
Comments GDP-D-α-D-lincosamide [i.e., GDP-6-amino 6(1-hydroxyethyl)galactose] is an intermediate in the formation of lyncomycin antibiotics in Streptomyces lincolnensis.
The enzyme LmbS (and also its homolog CcbS, from the Celesticetin biosynthesis pathway) catalyzes the reaction in the direction opposite to the one shown above.
Organisms -Eubacteria
Links Enzyme (activities) lmbs
BRENDA (activities) lmbs
KEGG (pathways) lmbs
PLPMDB (PLP mutants) lmbs
 Wang SA, Lin CI, Zhang J, Ushimaru R, Sasaki E, Liu HW (2020) Studies of lincosamide formation complete the biosynthetic pathway for lincomycin A Proc Natl Acad Sci U S A 117 24794-24801.

Articles on lmbs
last changed 2020/11/04 15:48

B6db activities