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B6db activities: mppp

Description Arginine 4-hydroxylase/deaminase (1.13.12.-)
Alternative names MppP (gene name);
RohP (gene name)
Catalyzed reaction L-arginine + 2O(2)+2H(2)O = (S)-4-hydroxy-2-ketoarginine + H(2)O(2)
Cofactor Pyridoxal phosphate
Comments The enzyme from S. waydamensis is involved in the Enduracididine Biosynthetic Pathway.
It yields a mixture of 2-oxo-4-hydroxy-5-guanidinovalerate and 2-oxo-5-guanidinovalerate in a 1.7:1 ratio.

PDB 5DJ1; 6C3B;
Organisms -Eubacteria


mppp (0)
Links Enzyme (activities) mppp
BRENDA (activities) mppp
KEGG (pathways) mppp
PLPMDB (PLP mutants) mppp
 Han L, Vuksanovic N, Oehm SA, Fenske TG, Schwabacher AW, Silvaggi N. (2018) Streptomyces wadayamensis MppP is a PLP-dependent oxidase, not an oxygenase Biochemistry 57 3252-3264.

 Hedges JB, Kuatsjah E, Du YL, Eltis LD, Ryan KS. (2018) Snapshots of the catalytic cycle of an O2, pyridoxal phosphate-dependent hydroxylase. ACS Chem Biol 13 965-974.

 Han L, Schwabacher AW, Moran GR, Silvaggi NR (2015) Streptomyces wadayamensis MppP Is a Pyridoxal 5'-Phosphate-Dependent L-Arginine α-Deaminase, γ-Hydroxylase in the Enduracididine Biosynthetic Pathway Biochemistry 54 7029-40.

Articles on mppp
last changed 2019/06/20 13:09

B6db activities