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B6db activities: mur24

mur24
Description Disaccharide alkyl acceptor aminobutyryltransferase (4.1.1.-)
Alternative names Aminobutyryl-transferase (ambiguous);
ABTase;
Mur24 (gene name).
Catalyzed reaction S-adenosyl-L-methionine + disaccharide alkyl acceptor = Aminobutyroylated disaccharide + methylthioadenosine.
Cofactor Pyridoxal-phosphate.
Catalyzes a gamma-substitution.
The validated bacterial enzyme is from a Streptomyces species and is involved in the biosynthesis of the dinucleoside core of muraymycins. Muraymycins are part of a broader group of antibiotics (including for example caprazamycin B and sphaerimicin A), which possess the same kind dinucleoside of core and which inhibit translocase I.
Organisms -Eubacteria
 

Family 

mur24 (5)
 
Links Enzyme (activities) mur24
BRENDA (activities) mur24
KEGG (pathways) mur24
PLPMDB (PLP mutants) mur24
 
References
 Cui Z, Overbay J, Wang X, Liu X, Zhang Y, Bhardwaj M, Lemke A, Wiegmann D, Niro G, Thorson JS, Ducho C, Van Lanen SG (2020) Pyridoxal-5'-phosphate-dependent Alkyl Transfer in Nucleoside Antibiotic Biosynthesis Nat Chem Biol in press.

Articles on mur24
 
last changed 2020/06/16 10:09

B6db activities