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B6db activities: nikk

Description Aminohexuronic acid aminotransferase (2.6.1.-)
Catalyzed reaction Ketohexuronic acid + L-glutamate = aminohexuronic acid + 2-oxoglutarate
Cofactor Pyridoxal phosphate
The enzyme nikk is an essential protein for nikkomycin biosynthesis.
Nikkomycins act as a competitive inhibitor of chitin synthetase and display potent activities against phytopathogenic and human pathogenic fungi.
Organisms -Eubacteria


nikk (0)
Links Enzyme (activities) nikk
BRENDA (activities) nikk
KEGG (pathways) nikk
PLPMDB (PLP mutants) nikk
 Binter A, Oberdorfer G, Hofzumahaus S, Nerstheimer S, Altenbacher G, Gruber K, Macheroux P. (2011) Characterization of the PLP-dependent aminotransferase NikK from Streptomyces tendae and its putative role in nikkomycin biosynthesis. FEBS J 278 4122-35.

Articles on nikk
last changed 2019/06/20 13:10

B6db activities