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B6db activities: psec

Description UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-4-hexulose aminotransferase (2.6.1.-)
Alternative names PseC.
Catalyzed reaction UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-4-hexulose + L-glutamate = UDP-4-amino-4,6-dideoxy-beta-L-AltNAc + 2-oxoglutarate.
Cofactor Pyridoxal phosphate.
Comments PseC is involved in the synthesis of the sialic acid-like nonulosonate, pseudaminic acid (Pse) by Helicobacter pylori. Pse is employed by the bacterium to glycosilate its own flagellin, and such glycosylation is essential for the assembly of functional flagellar filaments.
Organisms -Eubacteria


psec (3)
Links Enzyme (activities) psec
BRENDA (activities) psec
KEGG (pathways) psec
PLPMDB (PLP mutants) psec
 Schoenhofen IC, Lunin VV, Julien JP, Li Y, Ajamian E, Matte A, Cygler M, Brisson JR, Aubry A, Logan SM, Bhatia S, Wakarchuk WW, Young NM. (2006) Structural and functional characterization of PseC, an aminotransferase involved in the biosynthesis of Pseudaminic acid, an essential flagellar modification in helicobacter pylori. J Biol Chem. 281 8907-16.

Articles on psec
last changed 2010/01/27 17:52

B6db activities