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B6db activities: sbna

sbna
Description N-(1-amino-1-carboxyl-2-ethyl)-glutamate synthase (2.5.1.-)
Alternative names SbnA;
ACEGA synthase;
O-phosphoserine(amino)-lyase;
L-2,3-diaminopropionate synthase, protein A
Catalyzed reaction O-phospho-L-serine + L-glutamate = N-(1-amino-1-carboxyl-2-ethyl)-glutamate + phosphate
Cofactor Pyridoxal phosphate.
SbnA uses O-phospho-L-serine and L-glutamate to produce the unusual metabolite N-(1-amino-1-carboxyl-2-ethyl)-glutamic acid (ACEGA), which in turn is oxidatively hydrolyzed by a second protein (SbnB) to yield α-ketoglutarate and L-2,3-diaminopropionic acid. In Staphylococcus aureus, the SbnA reaction is the first in the synthesis of the siderophore staphyloferrin B.
Organisms -Bacteria
 

Family 

sbna (10)
 
Links Enzyme (activities) sbna
BRENDA (activities) sbna
KEGG (pathways) sbna
PLPMDB (PLP mutants) sbna
 
References
 Kobylarz MJ, Grigg JC, Takayama SJ, Rai DK, Heinrichs DE, Murphy M.E. (2014) Synthesis of L-2,3-diaminopropionic acid, a siderophore and antibiotic precursor Chem Biol. 21 379-88.

Articles on sbna
 
last changed 2014/07/04 14:34

B6db activities