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B6db activities: spnq

Description TDP-4-dehydro-2,6-dideoxy-D-glucose 3-dehydrase (1.17.1.-)
Alternative names TDP-4-oxo-2,6-dideoxy-D-glucose 3-dehydratase.
Catalyzed reaction TDP-4-dehydro-2,6-dideoxy-D-glucose + donor + H+ = dTDP-4-dehydro-2,3,6-trideoxy-D-glucose + oxidized donor + H2O
Cofactor Pyridoxamine-phosphate and iron-sulfur cluster.
Comments The reaction mechanism is analogous to that of CDP-6-deoxy-L-threo-D-glycero-4-hexulose 3-dehydrase (E.C.

This enzyme is involved in the biosynthesis of forosamine, a highly deoxygenated sugar found in several natural products, such as the insecticide spinosyns.
The reaction product (dTDP-4-dehydro-2,3,6-trideoxy-d-glucose) is the substrate of the transaminase SpnR.

Organisms -Eubacteria


spnq (3)
Links Enzyme (activities) spnq
BRENDA (activities) spnq
KEGG (pathways) spnq
PLPMDB (PLP mutants) spnq
References Articles on spnq
last changed 2009/07/29 13:35

B6db activities