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B6db activities: sxta

Description 4-amino-3-oxo-guandidinoheptane synthase (2.3.1.-)
Alternative names SxtA AONS domain
Catalyzed reaction propionyl-[acyl-carrier protein] + L-arginine = 4-amino-3-oxo-guandidinoheptane + acyl-carrier protein + CO(2).
Cofactor Pyridoxal-phosphate
Comments The enzyme is a C-terminal OAS domain of a four-domain polyketide-like synthase, SxtA, and catalyzes a C-C bond formation between the alpha-carbon of L-arginine and thioester carbon of the propionyl-ACP, in the saxitoxin biosynthesis. The activity is very similar to 8-amino-7-oxononanoate synthase (EC
Organisms -Eubacteria


sxta (0)
Links Enzyme (activities) sxta
BRENDA (activities) sxta
KEGG (pathways) sxta
PLPMDB (PLP mutants) sxta
 Chun SW, Hinze ME, Skiba MA, Narayan ARH (2018) Chemistry of a Unique Polyketide-like Synthase J Am Chem Soc. 140 2430-2433.

Articles on sxta
last changed 2019/06/20 13:20

B6db activities