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B6db activities: tuzn1299

Description Branched chain amino acid--pyruvate transaminase (low-specificity) (2.6.1.-)
Alternative names TUZN1299 (gene name);
VMUT0738 (gene name);
Catalyzed reaction 4-methyl-2-oxovalerate+alanine = leucine+ pyruvate
Cofactor Pyridoxal-phosphate
TUZN1299 was found to be highly active toward branched-chain amino acids (BCAAs), positively charged amino acids, l-methionine, l-threonine, l-homoserine, l-glutamine, as well as toward 2-oxobutyrate and keto analogs of BCAAs, whereas l-glutamate and α-ketoglutarate were not converted in the overall reaction. (This is a striking difference with respect to classic BCAATs, grouped in family
PDB 5CE8:;
Organisms -Archea


tuzn1299 (0)
Links Enzyme (activities) tuzn1299
BRENDA (activities) tuzn1299
KEGG (pathways) tuzn1299
PLPMDB (PLP mutants) tuzn1299
 Stekhanova TN, Rakitin AL, Mardanov AV, Bezsudnova EY, Popov VO (2017) A Novel highly thermostable branched-chain amino acid aminotransferase from the crenarchaeon Vulcanisaeta moutnovskia Enzyme Microb Technol 96 127-134.

 Bezsudnova EY, Stekhanova TN, Suplatov DA, Mardanov AV (2016) Experimental and computational studies on the unusual substrate specificity of branched-chain amino acid aminotransferase from Thermoproteus uzoniensis Arch. Biochem. Biophys. 607 27-36.

 Boyko KM, Stekhanova TN, Nikolaeva AY, Mardanov AV, Rakitin AL, Ravin NV, Bezsudnova EY, Popov VO (2016) First structure of archaeal branched-chain amino acid aminotransferase from Thermoproteus uzoniensis specific for L-amino acids and R-amines Extremophiles 20 215-25.

Articles on tuzn1299
last changed 2019/06/20 13:28

B6db activities