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B6db activities: arg.aminomutase

Description Arginine 2,3-aminomutase (5.4.3.-)
Alternative names blsG (gene name);
Catalyzed reaction L-arginine <=> 3-amino 5-guanidino pentanoate
Cofactor Pyridoxal-phosphate. S-adenosyl-L-methionine; [4Fe-4S] cluster
Comments The enzyme has been identified in Streptomyces griseochromogenes, where it is involved in the biosynthesis of the antibiotic blasticidin S.

The enzyme also acts on L-lysine. Cofactors have been inferred by similarity.

Organisms -Eubacteria


Links Enzyme (activities) arg_aminomutase
BRENDA (activities) arg_aminomutase
KEGG (pathways) arg_aminomutase
PLPMDB (PLP mutants) arg_aminomutase
 Zhao J, Ji W, Ji X, Zhang Q (2020) Biochemical Characterization of an Arginine 2,3‐aminomutase with Dual Substrate Specificity Chin. J. Chem. 38 in press.

 Cone MC, Yin X, Grochowski LL, Parker MR, Zabriskie TM. (2003) The blasticidin S biosynthesis gene cluster from Streptomyces griseochromogenes: sequence analysis, organization, and initial characterization Chembiochem 4 821-8.

 Prabhakaran P. C., Woo N-T., Yorgey P.S., Gould S.J. (1988) Biosynthesis of blasticidin S from L-alpha-arginine. Stereochemistry in the arginine-2,3-aminomutase reaction J. Am. Chem. Soc. 110 5785-91.

Articles on arg.aminomutase
last changed 2020/04/23 09:09

B6db activities