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B6db activities: asp-glu.1.decarboxylase

Description Aspartate/Glutamate 1-decarboxylase (4.1.1.-)
Catalyzed reaction L-aspartate = β-alanine + CO(2)
L-glutamate = 4-aminobutanoate + CO(2).
Cofactor Pyridoxal-phosphate.
The recombinant protein from T. kodakaensis prefers L-Asp as its substrate rather than L-Glu, with nearly a 20-fold difference in catalytic efficiency.

In other enzymes, the two aminoacids react with similar efficiencies, or L-Glu is preferred.

In metazoa, L-Asp decarboxylation is carried out by Sulfinoalanine decarboxylase (

Organisms -Archea
Links Enzyme (activities) asp-glu_1_decarboxylase
BRENDA (activities) asp-glu_1_decarboxylase
KEGG (pathways) asp-glu_1_decarboxylase
PLPMDB (PLP mutants) asp-glu_1_decarboxylase
References Articles on asp-glu.1.decarboxylase
last changed 2017/10/12 16:04

B6db activities