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B6db activities: aspartate.1.decarboxylase

aspartate_1_decarboxylase
Description aspartate_1_decarboxylase (4.1.1.-)
Catalyzed reaction L-aspartate = β-alanine + CO(2)
Cofactor Pyridoxal-phosphate.
The recombinant TK1814 protein displayed ADC activity using pyridoxal 5' -phosphate as a cofactor. Kinetic studies revealed that the TK1814 protein prefers Asp as its substrate rather than Glu, with nearly a 20-fold difference in catalytic efficiency.

In metazoa, this reaction is carried out by Sulfinoalanine decarboxylase (4.1.1.29).

Organisms -Archea
 

Family 

 
Links Enzyme (activities) aspartate_1_decarboxylase
BRENDA (activities) aspartate_1_decarboxylase
KEGG (pathways) aspartate_1_decarboxylase
PLPMDB (PLP mutants) aspartate_1_decarboxylase
 
References
 Hiroya Tomita, Yuusuke Yokooji, Takuya Ishibashi, Tadayuki Imanaka and Haruyuki Atomi (2014) An archaeal glutamate decarboxylase homolog functions as an aspartate decarboxylase and is involved in β-alanine and CoA biosynthesis. J Bacteriol. 1327-13.

 Eon-Seok Lee, Han-Woo Kim, Dong-Eun Kim, Yeon-Hee Kim, Soo-Wan Nam, Byung-Woo Kim, Sung-Jong Jeon (2013) Gene expression and characterization of thermostable glutamate decarboxylase from Pyrococcus furiosus Biotechnology and Bioprocess Engineering 18 375-381.

Articles on aspartate.1.decarboxylase
 
last changed 2014/02/26 11:44

B6db activities