B6db activities : ctaf

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	ctaf
Description	L-aspartyl-[CtaE acyl-carrier protein] decarboxylase (4.1.1.-)
Alternative names	L-aspartyl-[CtaE acyl-carrier protein] carboxy-lyase; CtaF.
Catalyzed reaction	L-aspartyl-[CtaE acyl-carrier protein] = beta alanyl-[CtaE acyl-carrier protein] + CO2 L-aspartyl-beta-alanyl-[CtaE acyl-carrier protein] = beta alanyl-beta alanyl-[CtaE acyl-carrier protein] + CO2
Cofactor	Pyridoxal-phosphate.
Comments	The enzyme from Ruminiclostridium cellulolyticum is involved in the biosynthesis of closthioamide (CTA), a rare example of a thioamide-containing nonribosomal peptide. In combination with the ligase CtaD, it can add up to three beta-alanyl moyeties to the CtaE carrier protein, generating the amide backbone of CTA.
Organisms	-Eubacteria
Family	ctaf (0)

Links	Enzyme (activities) ctaf BRENDA (activities) ctaf KEGG (pathways) ctaf PLPMDB (PLP mutants) ctaf

References	Dunbar KL, Dell M, Gude F, Hertweck C (2020) Reconstitution of polythioamide antibiotic backbone formation reveals unusual thiotemplated assembly strategy Proc Natl Acad Sci U S A 117 8850-8858. Articles on ctaf

last changed	2020/05/23 20:12

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