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cuab |
Description |
Curvulamine intermediate synthase (2.3.1.-) |
Alternative names |
cuaB (gene name);
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Catalyzed reaction |
3-oxo-4-hexenoyl-[acyl-carrier protein] + alanine + O(2) = [acyl-carrier protein] + 2-hydroxy-2-methyl-5-[(1E,3E)-penta-1,3-dien-1-yl]-1,2-dihydro-3H-pyrrol-3-one + CO(2) + H(2)O(2). |
Cofactor |
Pyridoxal phosphate. |
Comments |
The enzyme catalyzes an intermediate step in the biosynthesis of the indolizidine alkaloid Curvulamine.
CuaB acts on the highly reduced acyl chain produced by a polyketide synthase complex, releasing this chain from the acyl carrier protein (ACP) of the complex. Such a relaease entails a decarboxylative claisen condensation between L-alanine and acyl-S-ACP, followed by the reaction of the PLP-bound decarboxylated intermediate with molecular oxygen. |
Organisms |
-Fungi |
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Family |
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Links |
Enzyme (activities) cuab
BRENDA (activities) cuab
KEGG (pathways) cuab
PLPMDB (PLP mutants) cuab
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References |
Articles on cuab |
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last changed |
2019/12/28 16:41 |
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