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B6db activities: desv

desv
Description dTDP-3-dehydro-4,6-dideoxy-D-glucose aminotransferase (2.6.1.-)
Alternative names TDP-3-keto-4,6-dideoxy-D-glucose--glutamate aminotransferase;
DesV.
Catalyzed reaction TDP-3-dehydro-4,6-dideoxy-D-glucose + L-glutamate = TDP-3-amino-3,4,6-trideoxy-D-glucose + 2-oxoglutarate
Cofactor Pyridoxal-phosphate.
In Streptomyces venezuelae, the enzyme is involved in the biosynthesis of macrolide antibiotic. The DesV gene product catalyzes the fifth step in the process (hence the name).

The transamination reaction (shown above) is very similar to that catalyzed by TylB in S. fradiae, and the enzymes are also phylogenetically very close.

PDB 2OGE;
Organisms -Eubacteria
 

Family 

desv (4)
 
Links Enzyme (activities) desv
BRENDA (activities) desv
KEGG (pathways) desv
PLPMDB (PLP mutants) desv
 
References Articles on desv
 
last changed 2010/01/27 18:00

B6db activities