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B6db activities: dhph-n

Description 1-​amino-​2-​(phosphohydroxy)​ethyl​-phosphonate phospho-lyase (4.2.3.-)
Alternative names DhpH N-terminal domain;
Catalyzed reaction [1-​amino-​2-​(phosphohydroxy)​ethyl]​-phosphonate + H(2)O = = [1-​oxo-​ethyl]​-phosphonate + + NH(3) + phosphate.
Cofactor Pyridoxal-phosphate
Involved in biosynthesis of the broad-spectrum antibiotic dehydrophos.

The reaction is catalyzed by the N-terminal domain of the DhpH gene product. The [1-​oxo-​ethyl]​-phosphonate, generated by this reaction is used as a substrate by DhpD, a second PLP-dependent enzyme in the dehydrophos pathway.
In turn, the DhpD product (1-amino-phosphonoethane) is condensed with a Leu molecule by the C-terminal domain of DhpH.

Organisms -Eubacteria


dhph-n (0)
Links Enzyme (activities) dhph-n
BRENDA (activities) dhph-n
KEGG (pathways) dhph-n
PLPMDB (PLP mutants) dhph-n
 Bougioukou DJ, Mukherjee S, van der Donk WA (2013) Revisiting the biosynthesis of dehydrophos reveals a tRNA-dependent pathway Proc Natl Acad Sci U S A 110 10952-7.

Articles on dhph-n
last changed 2019/06/20 13:07

B6db activities