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B6db activities: frbh

Description CMP-5'-2-amino-phosphonobutyrate decarboxylase (4.1.1.-)
Catalyzed reaction CMP-5'-2-ammino-phophonobutyrate = CMP-5'-3-amminopropylphosphonate + CO(2)
Cofactor Pyridoxal phosphate
The enzyme frbh has two distinct domains, an N-terminal nucleotide transferase domain followed by a PLP-dependent aminotransferase/decarboxylase domain. The nucleotide transferase domain catalyzes the convertion of 4-phosphono-2-aminobutyrate to CMP-5'-2-amino-phosphonobutyrate.
The enzyme from Streptomyces rubellomurinus is involved in the biosynthetic pathway of the antimalarial antibiotic FR-900098.
Organisms -Eubacteria


frbh (0)
Links Enzyme (activities) frbh
BRENDA (activities) frbh
KEGG (pathways) frbh
PLPMDB (PLP mutants) frbh
 Johannes TW, DeSieno MA, Griffin BM, Thomas PM, Kelleher NL, Metcalf WW, Zhao H. (2010) Deciphering the late biosynthetic steps of antimalarial compound FR-900098. Chemistry & biology 17 57-64.

Articles on frbh
last changed 2018/04/11 13:07

B6db activities