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fum8 |
Description |
Fumonisin B1 synthase (2.3.1.-) |
Alternative names |
Polyketide Chain Releasing enzyme;
alpha-Oxoamine Synthase (ambiguous).
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Catalyzed reaction |
polyketide-[acyl-carrier protein] + alanine = [acyl-carrier protein] + fumonisin B1 + CO(2). |
Cofactor |
Pyridoxal phosphate. |
Comments |
The enzyme catalyzes the last step in the biosynthesis of the polyketide-based mycotoxin Fumonisin B1.
Fum8 acts on the highly reduced acyl chain produced by a polyketide synthase complex, releasing this chain from the acyl carrier protein (ACP) of the complex. Such a relaease entails a decarboxylative condensation between L-alanine and acyl-S-ACP. |
Organisms |
-Fungi |
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Family |
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Links |
Enzyme (activities) fum8
BRENDA (activities) fum8
KEGG (pathways) fum8
PLPMDB (PLP mutants) fum8
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References |
Articles on fum8 |
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last changed |
2009/07/07 16:08 |
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