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B6db activities: genb1

Description 6'-deoxy-6'(S)-amino-geneticin aminotransferase (2.6.1.-)
Catalyzed reaction 6'-deidro -6'-oxo-genltamicin+L-glutamate=>6'-deoxy-6(S)-amino-geneticin +2-oxoglutarate.
Cofactor Pyridoxal phosphate
Comments The enzyme is part of the biosynthesis of Gentamicin C Complex.
PDB 6CBO; 5Z83;
Organisms -Eubacteria


genb1 (0)
Links Enzyme (activities) genb1
BRENDA (activities) genb1
KEGG (pathways) genb1
PLPMDB (PLP mutants) genb1
 Ban YH, Song MC, Hwang JY, Shin HL, Kim HJ, Hong SK, Lee NJ, Park JW, Cha SS, Liu HW, Yoon YJ (2019) Complete reconstitution of the diverse pathways of gentamicin B biosynthesis Nat Chem Biol 15 295-303.

 Dow GT, Thoden JB, Holden HM (2018) The Three-Dimensional Structure of NeoB: An Aminotransferase Involved in the Biosynthesis of Neomycin Protein Sci 27 945-956.

 Gu Y, Ni X, Ren J, Gao H, Wang D, Xia H. (2015) Biosynthesis of Epimers C2 and C2a in the Gentamicin C Complex. Chembiochem. 16 19331942.

Articles on genb1
last changed 2019/01/21 12:50

B6db activities