Activities | Families | Sequences | Fold types | References | Help
B6db activities: hape

Description L-cysteine desulfurase/desulfhydrase (4.4.1.-)
Catalyzed reaction L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine
L-Cysteine + H(2)O = pyruvate + H(2)S + NH(3).
Cofactor Pyridoxal-phosphate.
The recombinant protein from Mycoplasma pneumoniae is threefold more active as a desulfurase than as a desulfhydrase, but the desulfhydrase reaction seems important for pathogenesis.

Organisms -Eubacteria


hape (0)
Links Enzyme (activities) hape
BRENDA (activities) hape
KEGG (pathways) hape
PLPMDB (PLP mutants) hape
 Großhennig S, Ischebeck T, Gibhardt J, Busse J, Feussner I, Stülke J (2016) Hydrogen sulfide is a novel potential virulence factor of Mycoplasma pneumoniae: characterization of the unusual cysteine desulfurase/desulfhydrase HapE Mol Microbiol 100 42-54.

Articles on hape
last changed 2019/06/20 13:08

B6db activities