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B6db activities: hpgt.aminotransferase

HpgT_aminotransferase
Description L-4-hydroxyphenylglycine aminotransferase (2.6.1.-).
Alternative names L-p-hydroxyphenylglycine transaminase.
Catalyzed reaction 4-hydroxyphenylglyoxylate + L-tyrosine = L-4-hydroxyphenylglycine + 4-hydroxyphenylpyruvate
Cofactor Pyridoxal-phosphate.
The enzyme serves to the production of 4-hydroxyphenylglycine, a component of some bioactive peptides formed by non-ribosomal synthesis.

Enzymes with this activity have been described in Amycolatopsis orientalis (intervening in the synthesis of chloroeremomycin) and Streptomyces lavendulae (synthesis of complestatin). They do not use D-p-hydroxyphenylglycine as a substrate and thus are totally distinct from EC 2.6.1.72.

Organisms -Eubacteria
 

Family 

 
Links Enzyme (activities) HpgT_aminotransferase
BRENDA (activities) HpgT_aminotransferase
KEGG (pathways) HpgT_aminotransferase
PLPMDB (PLP mutants) HpgT_aminotransferase
 
References
 Chiu, H. T.; Hubbard, B. K.; Shah, A. N.; Eide, J.; Fredenburg, R. A.; Walsh, C. T.; Khosla, C. (2001) Molecular cloning and sequence analysis of the complestatin biosynthetic gene cluster Proc Natl Acad Sci U S A 98 8548-53.

 Hubbard BK, Thomas MG, Walsh CT. (2000) Biosynthesis of L-p-hydroxyphenylglycine, a non-proteinogenic amino acid constituent of peptide antibiotics Chem Biol 7 931-42.

Articles on hpgt.aminotransferase
 
last changed 2010/01/27 17:58

B6db activities