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l-lysine_2-aminotransferase |
Description |
L-lysine 2-aminotransferase (2.6.1.-) |
Alternative names |
BomE (gene name); |
Catalyzed reaction |
L-lysine + pyruvate = 2-oxo-6-aminohexanoate + L-alanine. |
Cofactor |
Pyridoxal-phosphate. |
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Other ketoacids can function as acceptors of the amino group.
Apparently, the 2-oxo-6-aminohexanoate product readily rearranges to a cyclic, dehydrated form, piperideine-2-carboxylate, which is a precursor in the biosynthesis of some antibiotics. |
Organisms |
-Eubacteria |
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Family |
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Links |
Enzyme (activities) l-lysine_2-aminotransferase
BRENDA (activities) l-lysine_2-aminotransferase
KEGG (pathways) l-lysine_2-aminotransferase
PLPMDB (PLP mutants) l-lysine_2-aminotransferase
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References |
Yun X, Zhang Q, Lv M, Deng H, Deng Z, Yu Y. (2019) In vitro reconstitution of the biosynthetic pathway of 3-hydroxypicolinic acid Org Biomol Chem 17 454-460. Xu B, Fan Z, Lei Y, Ping Y, Jaisi A, Xiao Y (2018) Insights into Pipecolic Acid Biosynthesis in Huperzia serrata Org Lett 20 2195-2198. Lv M, Zhao J, Deng Z, Yu Y (2015) Characterization of the Biosynthetic Gene Cluster for Benzoxazole Antibiotics A33853 Reveals Unusual Assembly Logic Chem Biol 22 1313-24. Namwat, W.; Kinoshita, H.; Nihira, T. (2002) Identification by heterologous expression and gene disruption of VisA as L-lysine 2-aminotransferase essential for virginiamycin S biosynthesis in Streptomyces virginiae J Bacteriol 184 4811-8. Bruntner, C.; Bormann, C. (1998) The Streptomyces tendae Tu901 L-lysine 2-aminotransferase catalyzes the initial reaction in nikkomycin D biosynthesis Eur J Biochem 254 347-55. Articles on l-lysine.2-aminotransferase |
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last changed |
2018/02/16 18:43 |
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