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lipo |
Description |
L-methionine--uridine-5'-aldehyde aminotransferase (2.6.1.-) |
Alternative names |
LipO (gene name);
Pac5 (gene name);
Mur20 (gene name); |
Catalyzed reaction |
L-methionine + uridine-5'-aldehyde = 4-methylthio-2-oxobutanoate + 5'-aminouridine. |
Cofactor |
Pyridoxal phosphate |
Comments |
Involved in the biosynthesis of nucleoside antibiotics such as liposidomycin and in peptidoglycan cell wall biosynthesis.
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These aminotransferases can apparently use different amino group donors, but the enzymes from Streptomyces sp. SANK 60405 and Streptomyces roseoverticillatus (aka Streptoverticillium fervens) reportedly use L-methionine as the preferred amino group donor. |
Organisms |
-Eubacteria |
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Family |
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Links |
Enzyme (activities) lipo
BRENDA (activities) lipo
KEGG (pathways) lipo
PLPMDB (PLP mutants) lipo
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References |
Cui Z, Liu X, Overbay J, Cai W, Wang X, Lemke A, Wiegmann D, Niro G, Thorson JS, Ducho C, Van Lanen SG (2018) Enzymatic Synthesis of the Ribosylated Glycyl-Uridine Disaccharide Core of Peptidyl Nucleoside Antibiotics J Org Chem 83 7239-7249. Hiratsuka T, Suzuki H, Kariya R, Seo T, Minami A, Oikawa H. (2014) Biosynthesis of the structurally unique polycyclopropanated polyketide-nucleoside hybrid jawsamycin (FR-900848). Angew Chem Int Ed Engl. 53 5423-6. Chi X, Pahari P, Nonaka K, Van Lanen SG. (2011) Biosynthetic origin and mechanism of formation of the aminoribosyl moiety of peptidyl nucleoside antibiotics. J Am Chem Soc. 133 14452-9. Ragab AE, Grüschow S, Tromans DR, Goss RJ (2011) Biogenesis of the unique 4',5'-dehydronucleoside of the uridyl peptide antibiotic pacidamycin J Am Chem Soc. 133 15288-91. Articles on lipo |
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last changed |
2019/12/28 20:20 |
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